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- W2366985703 abstract "Objective:To investigate the effects of Paridis saponin Ⅱ on the TGF-β and IL-10,which were secreted by CD4+CD25+ T regulation cells from the peripheral blood of LN patients.Methods:10 healthy person were composed to the normal control group,and the 20 LN patients were divided into 4 groups randomly:the LN control group(n=5),the first Paridis saponin Ⅱ group(n=5,added Paridis saponin Ⅱ was 1×105/1.5ml/ pore),the second Paridis saponin Ⅱ group(n=5,added Paridis saponin Ⅱ was 2×105/1.5ml/pore),the third Paridis saponin Ⅱ group(n=5,added Paridis saponin Ⅱ was 5 ×105/1.5ml/ pore).Isolate peripheral blood mononuclear cells(PBMC) and then isolate CD4+CD25+ Treg with MACS.Added in Paridis saponin Ⅱ to Paridis saponin Ⅱ groups,and nothing to the normal control group and the LN control group.The 5 groups were cultured for 72 hours.ELISA was used to analyze the level of TGF-β and IL-10 in the supernatant.Results:The level of TGF-β and IL-10 were significant lower in LN groups than those in control group(P0.01).The level of TGF-β and IL-10 were higher in the groups which were cultured with Paridis saponin Ⅱ than the group without the treatment(P0.05).Among the groups which were cultured with Paridis saponin Ⅱ,the level of TGF-β and IL-10 of the second group was significant higher than the first and the third(P0.01).The change of the first and the third was not significant obvious(P0.05).Conclusion:Paridis saponin Ⅱ can increase the LN patients' level of TGF-β and IL-10.The range of increase was influenced by the quantities of the added cells." @default.
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- W2366985703 date "2010-01-01" @default.
- W2366985703 modified "2023-09-27" @default.
- W2366985703 title "The effects of Paridis saponin II on the production of cell cytokines in CD4+CD25+T regulation cells from lupus nephritis patients' peripheral blood." @default.
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