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- W2366992417 abstract "The purpose of this study was to assess the ability of adjuvants to enhance Staphylococcus aureus-directed responses following immunization with CP8-FnBPB-ClfA.Healthy adult female New Zealand big ear white rabbits were immunized with either PBS or purified CP8-FnBPBClfA with Freund's adjuvant,ALUM,liposome or heat-labile enterotoxin,B subunit fromEscherichia coli(LTB).Immune reactivity to CP8,FnBPB,ClfA,FnBPB-ClfA and CP8-FnBPB-ClfA was assessed over 60 days by ELISA and western blot.The levels of IL-2,IL-4,IL-10 and IFN-γwere detected by ELISA,the ability of CP8-FnBPB-ClfA to stimulate T cell proliferation was assessed by ex vivo culture and the toxicity test was chosen to detect antibody levels.The adjuvant LTB elicited the best lived CP8-FnBPB-ClfA specific antibody response,closely followed by ALUM and Freund's adjuvant.Although the liposome adjuvant group elicited CP8-FnBPB-ClfA antibodies earlier,this response was the shortest lived.Vaccination with ALUM and LTB effectively elicited both Th1 cytokines,IFN-γand IL-2,which participate in cellular immune responses,and the Th2 cytokines,IL-4and IL-10,which participate in humoral.Adjuvant LTB had the strongest multiplication capacity of T lymphocyte.Immunization of rabbits with CP8-FnBPB-ClfA with the LTB adjuvant elicited strong and long lasting of adaptive humoral and cellular immune responses.The survival rate reached 80%." @default.
- W2366992417 created "2016-06-24" @default.
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- W2366992417 date "2015-01-01" @default.
- W2366992417 modified "2023-09-26" @default.
- W2366992417 title "The effect of different adjuvants multivalent virulence factor vaccine immunized on mastitis caused by Staphylococcus aureus" @default.
- W2366992417 hasPublicationYear "2015" @default.
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