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- W2367024989 abstract "Objective:To investigate the effect of immunologic molecules in development of aplastic anemia(AA) and its clinical significance. Methods: Enzyme-linked immunoadsorbent assay(ELISA) were employed to determine the levels of interleukin-2(IL-2),flt3 ligand (FL) ,and soluble Fas ligand(sFasL) peripheral blood(PB) and bone manow(BM) of AA patients. Results:The levels of IL-2 in PB and BM of AA patients increased significantly in comparison with controls, especially in those with serious AA( P 0.05). The levels of soluble Fas li-gand(sFasL) increased in most of patients.The levels of FL was 25 times as high as those in controls and the levels in PB or BM were no statistical difference.The levels of those immunologic molecules would decrease after effective treatment, but the levels of sFasL and FL didn' t return to normal. Dynamic monitoring showed that the levels of IL-2,sFasL and F1 were paralled to clinical outcome.Conclusion: Highly elevated IL-2,FL and sFasL in PB and BM of AA patients were characteristic changes during the process of the disease and contributed to its disturbance of immunologic system. Dynamic monitoring the levels of these molecules may represent an important prognostic factor of the likely outcome in AA patients." @default.
- W2367024989 created "2016-06-24" @default.
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- W2367024989 date "2002-01-01" @default.
- W2367024989 modified "2023-09-27" @default.
- W2367024989 title "The changes of immunologic molecules in bone marrow and peripheral blood of aplastic anemia patients and its implication on clinical outcome" @default.
- W2367024989 hasPublicationYear "2002" @default.
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