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- W2367047119 abstract "Objective To study the effect of hepatocyte cytochrome p450 1A1 expression in rat nonalcoholic steatosis model.Methods Fourty Wistar rats were randomly divided into control group and high-fat diet group, and high-fat diet group was divided into 4 subgroups (2,4,8 and 12weeks). Each subgroup had 8 rats.The expression of hepatocyte cytochrome p450 1A1 antigen in rat nonalcoholic steatosis model induced by high fat diet was detected with immohistochemistry and Western blot.Meanwhile, levels of malondialdehyde (MDA) in liver tissue were detected by using thio-barbituric acid.Results Levels of MDA in liver tissue and the expression of hepatocyte cytochrome p450 1A1 antigen in rat nonalcoholic steatosis model induced by high fat diet were significantly increased than those in normal . There were significant positive correlation between those and degree of nonalcoholic steatosis.Conclusion Nonalcoholic steatosis induced liver damage was associated with a generalized induction of hepatocyte cytochrome p450 1A1 and lipid peroxidation." @default.
- W2367047119 created "2016-06-24" @default.
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- W2367047119 date "2005-01-01" @default.
- W2367047119 modified "2023-09-23" @default.
- W2367047119 title "Effect of hepatocyte cytochrome p450 1A1 in nonalcoholic steatosis rats" @default.
- W2367047119 hasPublicationYear "2005" @default.
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