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- W2367050176 abstract "Objective To investigate the synergism and mechanisms of transplantaion of controlled-release biomaterial of glial cell lined-derived neurotrophic factor(GDNF)on the motor neurons repair when transplantation with neuron-like cells after spinal cord injury of macaca mulatta.Methods Three groups of spinal cord paraffin specimens of macaca mulatta were collected,every group including 4 cases.Anterior motor neurons were counted and immunohistochemical method and image analysis system were applied in order to observe the expressing of bcl-2 and bax protein.Results Much more neurons could been observed in combined transplantation group and simple cell transplantation group,hardly any neurons could been observed in PBS control group(P0.01).Higher measurement data was observed in the combined transplantation group than the simple cell transplantation group on the average of Absorbance of bcl-2 protein(P0.05),but not bax protein.Conclusions Neuron-like cells derived from MSCs transplantion with GDNF produced much more stronger neuroprotective effect than only cells transplantation,which may be relate to the enhanced expressing of bcl-2 protein." @default.
- W2367050176 created "2016-06-24" @default.
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- W2367050176 date "2008-01-01" @default.
- W2367050176 modified "2023-09-23" @default.
- W2367050176 title "Synergy between controlled release biomaterial of GDNF and neuron-like cells derived from mesenchymal stem cells on the spinal cord anterior motor neurons repair and bcl-2/bax protein expression of mucaca multta" @default.
- W2367050176 hasPublicationYear "2008" @default.
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