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- W2367053416 abstract "BACKGROUND AND AIM: To explore the effects of subchronic exposure to di-n-butyl phthalate(DBP)on testicular insulin-like factor 3(Insl3)mRNA expression in pubertal male rats.MATERIALS AND METHODS: A total of 72 male Sprague-Dawley rats at the age of 4-5 weeks were equally randomized into 3 groups,to receive by gavage 0,50 or 250 mg/kg of DBP on alternate day for 90 days.Body,testis,epididymis and main organs were weighed.Serum testosterone,and mRNA expression of Insl3 in the testis were measured.RESULTS: There was an increase of the liver/body ratio in 250 mg/kg group after 90 days treatment(P0.05).Compared with the control,an increase in serum testosterone was found in the 50 mg/kg group(P0.05),but there was a reduction in 250 mg/kg group compared with the 50 mg/kg group(P0.01)after 60 days exposure.The mRNA expressions of Insl3 were significantly down regulated in all dosage groups(P0.01),more significantly in 250 mg/kg group than in 50 mg/kg group(P0.05).CONCLUSION: Pubertal male rats subchronically exposed to DBP could induce changes in serum testosterone and testicular Insl3 mRNA expression,and could have potential adverse effect on the liver." @default.
- W2367053416 created "2016-06-24" @default.
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- W2367053416 date "2009-01-01" @default.
- W2367053416 modified "2023-09-26" @default.
- W2367053416 title "Effects of Di-n-butyl Phthalate on Testicular Insl3 mRNA Expression in Pubertal Male Rats" @default.
- W2367053416 hasPublicationYear "2009" @default.
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