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- W2367063729 abstract "Objective To study the expression of vascular endothelial growth factor C(VEGF-C) and its receptor vascular endothelial growth factor receptor 3(VEGFR-3) in colorectal carcinoma and its relation with lymph node metastasis.Methods The specimens were taken from 56 patients with primary colorectal cancer in 2006.Twenty adenoma specimens were used as control.Be studied the expressions of VEGF-C protein,VEGFR-3 protein and CD34 protein in colorectal cancer and adenoma by immunohistochemistry.Results(1)The expressions of VEGF-C protein and VEGFR-3 protein were significantly higher than that in controls(P0.05).There was correlated expression between VEGF-C protein and VEGFR-3 protein.(2)The lymphatic microvessel density(LMVD) and microvessel dencity(MVD) were significantly higher than that in colorectal adenoma(all P0.05).The LMVD was higher in colorectal cancer with VEGF-C staining positive than that in VEGF-C staining negative group(P0.05).But the MVD had no significantly difference in VEGF-C staining positive group and in VEGF-C negative group(P0.05).Conclusion(1)the expression of VEGF-C protein and VEGFR-3 protein are higher in colorectal cancer than in adenoma,and it may correlated with lymph node metastsis.(2)the expression of VEGF-C protein is correlated with LMVD,but there is no significantly correlation between the expression of VEGF-C and MVD.(3)the raise of LMVD may promote lymph node metastasis of cancer cells." @default.
- W2367063729 created "2016-06-24" @default.
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- W2367063729 date "2009-01-01" @default.
- W2367063729 modified "2023-09-23" @default.
- W2367063729 title "The Expression of VEGF-C、VEGFR-3 in Primary Colorectal Carcinoma and the Relation with Lymph Node Metastasis" @default.
- W2367063729 hasPublicationYear "2009" @default.
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