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- W2367064208 abstract "In the model of reperfusion arrhythmias generated by ligation of left coronaryartery for 5 min followed by 15 min recirculation,eyproheptadine(Cyp,11.4×10- 6 mol ·kg-1,iv) significantly reduced the incidence of reperfusion arrhytthmias (RAr), abolished ventricular fibrillation (VF) and tachycardia (VT),markedly decreased the number of totalpremature ventricular complexes (PVC),slowed down heart rate, lowered the amplitude of P and T waves in ECG(Ⅱlead) and prevented the rise of ST segment caused by ischemia. In the isolated rat heart subjected to 30 min global ischemia and 20 min reperfusion, Cyp (20×10-6mol·L-1) obviously alleviated Ca2+ accumulation and K+ loss in reperfused myocardium, elevated energy charge (EC) markedly and adenosine triphosphate (ATP) level slightly, and reduced adenosine monophosphate (AMP) and inosine (INO) content very much. The results indicated that Cyp possessed antagonizing action on arrhythmias induced by ischemia and repexfusion. Besides, it can antagonize Ca2+, modify K+and improve energy metabolism in reperfusedmyocardium." @default.
- W2367064208 created "2016-06-24" @default.
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- W2367064208 date "1994-01-01" @default.
- W2367064208 modified "2023-09-25" @default.
- W2367064208 title "Antiarrhythmic effect of cyproheptadine and its role on myocardial metabolism" @default.
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