Matches in SemOpenAlex for { <https://semopenalex.org/work/W2367074578> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2367074578 abstract "Objective:To investigate the correlation between the expression of HMGB1 and the airway remodeling,pulmonary vascular reconstruction in COPD.Methods:24 SD rats were divided into 3 groups randomly.Healthy control group(Group A):rats were bred for 6 weeks in normal circumstance before controlling a test later.COPD group(Group B):200 μg LPS was instilled intratracheally once on d1 and d14 in all rats.These rats were exposed to cigarette smoke 1 h/d for 6 weeks.COPD and chronic hypoxia group(Group C):200 μg LPS was instilled intratracheally once on d1 and d14 and the rats were exposed to cigarette smoke 1 h/d for 6 weeks.In the last 2 weeks chronic hypoxia(FiO2=0.18) 8 h/d were performed simultaneously.We studied airway wall remodeling and morphologic changes of small pulmonary arteries.The positive expression of HMGB1 in lung tissue was examined by Western blot.Results:①Compared with group A,the ratio of bronchial wall thickness over bronchial external diameter(MT%)and the ratio of bronchial wall area over total area(MA%)were significantly higher in group BC(P0.05).②The muscularization of intra-aveolar arteries in group BC was more severe than that in group A(P0.05).The cross-sectional medial vascular wall area of pulmonary arteries was increased significantly in group C(P0.05).③Western blot showed that compared with group A,the expression of HMGB1 protein in group BC was significantly increased(P0.05).The expression of HMGB1 protein in group C was higher than that of group B(P0.05).Conclusion:With the progression of COPD,the airway remodeling and pulmonary vascular reconstruction aggravates progressively,while the expression of HMGB1 is increased in lung tissue.There may be some relevance between the expression of HMGB1 and the airway remodeling,and pulmonary vascular reconstruction." @default.
- W2367074578 created "2016-06-24" @default.
- W2367074578 creator A5054666711 @default.
- W2367074578 date "2012-01-01" @default.
- W2367074578 modified "2023-09-24" @default.
- W2367074578 title "The correlation between the expression of HMGB1 and the airway remodeling,pulmonary vascular reconstruction in rats with chronic obstructive pulmonary disease and clinical significance" @default.
- W2367074578 hasPublicationYear "2012" @default.
- W2367074578 type Work @default.
- W2367074578 sameAs 2367074578 @default.
- W2367074578 citedByCount "0" @default.
- W2367074578 crossrefType "journal-article" @default.
- W2367074578 hasAuthorship W2367074578A5054666711 @default.
- W2367074578 hasConcept C104317684 @default.
- W2367074578 hasConcept C105922876 @default.
- W2367074578 hasConcept C126322002 @default.
- W2367074578 hasConcept C142724271 @default.
- W2367074578 hasConcept C164705383 @default.
- W2367074578 hasConcept C178790620 @default.
- W2367074578 hasConcept C185592680 @default.
- W2367074578 hasConcept C2776415932 @default.
- W2367074578 hasConcept C2776780178 @default.
- W2367074578 hasConcept C2776914184 @default.
- W2367074578 hasConcept C2777714996 @default.
- W2367074578 hasConcept C2780545709 @default.
- W2367074578 hasConcept C42219234 @default.
- W2367074578 hasConcept C540031477 @default.
- W2367074578 hasConcept C55493867 @default.
- W2367074578 hasConcept C71924100 @default.
- W2367074578 hasConcept C7836513 @default.
- W2367074578 hasConcept C86803240 @default.
- W2367074578 hasConceptScore W2367074578C104317684 @default.
- W2367074578 hasConceptScore W2367074578C105922876 @default.
- W2367074578 hasConceptScore W2367074578C126322002 @default.
- W2367074578 hasConceptScore W2367074578C142724271 @default.
- W2367074578 hasConceptScore W2367074578C164705383 @default.
- W2367074578 hasConceptScore W2367074578C178790620 @default.
- W2367074578 hasConceptScore W2367074578C185592680 @default.
- W2367074578 hasConceptScore W2367074578C2776415932 @default.
- W2367074578 hasConceptScore W2367074578C2776780178 @default.
- W2367074578 hasConceptScore W2367074578C2776914184 @default.
- W2367074578 hasConceptScore W2367074578C2777714996 @default.
- W2367074578 hasConceptScore W2367074578C2780545709 @default.
- W2367074578 hasConceptScore W2367074578C42219234 @default.
- W2367074578 hasConceptScore W2367074578C540031477 @default.
- W2367074578 hasConceptScore W2367074578C55493867 @default.
- W2367074578 hasConceptScore W2367074578C71924100 @default.
- W2367074578 hasConceptScore W2367074578C7836513 @default.
- W2367074578 hasConceptScore W2367074578C86803240 @default.
- W2367074578 hasLocation W23670745781 @default.
- W2367074578 hasOpenAccess W2367074578 @default.
- W2367074578 hasPrimaryLocation W23670745781 @default.
- W2367074578 hasRelatedWork W2352348629 @default.
- W2367074578 hasRelatedWork W2352618647 @default.
- W2367074578 hasRelatedWork W2354676819 @default.
- W2367074578 hasRelatedWork W2355662513 @default.
- W2367074578 hasRelatedWork W2357282514 @default.
- W2367074578 hasRelatedWork W2367191067 @default.
- W2367074578 hasRelatedWork W2370256064 @default.
- W2367074578 hasRelatedWork W2370982341 @default.
- W2367074578 hasRelatedWork W2373306607 @default.
- W2367074578 hasRelatedWork W2378771243 @default.
- W2367074578 hasRelatedWork W2381312792 @default.
- W2367074578 hasRelatedWork W2382848041 @default.
- W2367074578 hasRelatedWork W2382965862 @default.
- W2367074578 hasRelatedWork W2383040663 @default.
- W2367074578 hasRelatedWork W2383752488 @default.
- W2367074578 hasRelatedWork W2392477645 @default.
- W2367074578 hasRelatedWork W2396363592 @default.
- W2367074578 hasRelatedWork W2420946484 @default.
- W2367074578 hasRelatedWork W3029420000 @default.
- W2367074578 hasRelatedWork W3030285941 @default.
- W2367074578 isParatext "false" @default.
- W2367074578 isRetracted "false" @default.
- W2367074578 magId "2367074578" @default.
- W2367074578 workType "article" @default.