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- W2367078889 abstract "Purpose To explore the role of granzyme B in the pathogenesis of viral myocarditis. Met hods Forty 4 week old BALB/c male mice were randomly divided into the experimental group ( n =20) and the control group ( n =20),inoculated intraperitoneally with Coxsackie B3 virus and Eagle′s solution res pectively .On day seven,all the mice were sacrificed and the hearts taken out for routine HE inspection.In situ hybridization was performed for the detection of granzyme B mRNA.Semi quantative analysis was used for the quantification of the myocardial histopathological area and the positive hybridization signal area.In addition the relationship between the granzyme B expression level and the myocardial lesion was investiga ted . Results Granzyme B mRNA was detected positive in the infiltrating cells in the myocardium of sixteen mice in the experimental group,the positive ratio was 80%;while no granzyme B mRNA was found in the control group.The expression of granzyme B was shown to be significantly positively correlated with the histopathological area ( r =0.88, P 0.05). Conclusions Granzyme B might play some role in the pathogenesis of viral myocarditis." @default.
- W2367078889 created "2016-06-24" @default.
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- W2367078889 date "2000-01-01" @default.
- W2367078889 modified "2023-09-25" @default.
- W2367078889 title "In Situ Detection of Granzyme B in the Infiltrating Cells in the Myocardium of Murine Coxsackie B3 Viral Myocarditis" @default.
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