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- W2367079081 abstract "Objective To study the effect of Yikunning(traditional Chinese medicines)on the expression of estrogen receptor α,β in rat ovaries during perimenopause period and investigate the mechanism of Chinese medicine Yikunning on perimenopausal syndrome.Methods Thirty female Wistar rats of 12 month old were randomly divided into three groups:old control group,livial group,Yikunning group.Ten female rats of 5 month old were selected as young control group,and gavaged with corresponding drugs for 4 weeks.The expression of ER α,β mRNA and protein were detected by RT-PCR and immunohistochemistry.Results The results of RT-PCR and immunohistochemistry showed that the expressions of ER α and ER β in ovaries were decreased significantly in aging model group,compared with that in young control group(P0.01).The expressions of ER α and ER β in ovaries were significantly increased in Yikunning group and Livial group,compared with that in aging model group(P0.05 or P0.01).Conclusions Yikunning could up-regulate the expression of ERα and ER β,which may be one of the treatment mechanisms of Yikunning on perimenopausal syndrome." @default.
- W2367079081 created "2016-06-24" @default.
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- W2367079081 date "2008-01-01" @default.
- W2367079081 modified "2023-09-24" @default.
- W2367079081 title "Effects of Chinese medicine Yikunning on the expression of estrogen receptors in rat ovaries during perimenopausal period" @default.
- W2367079081 hasPublicationYear "2008" @default.
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