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- W2367079680 abstract "Objective To investigate changes of apoptosis induce factor(AIF) and the influence of poly(adenosine diphosphate-ribose) polymerase(PARP) inhibitor,3-aminobenzamide(3-AB) on AIF level in rat hippocampus after seizures.Methods(1) 30 Wistar rats were devided into control group and epileptic 3 h,8 h,24 h,72 h groups(Ep 3 h,Ep 8 h,Ep 24 h,Ep 72 h group) randomly,and 6 rats in each group.Seizures were induced by Li-pilocarpine through intraperitoneal injection.Rats were capitalized at corresponding time points.Western blot analysis was used to detect AIF levels in mitochondria and nucleus in hippocampus.(2) 18 Wistar rats were divided into control group,Li-pilocarpine group and 3-AB group randomly,and 6 rats in each group.3-AB was intraperitoneal injection at 40 mg/kg in 3-AB group 30 min before seizures.Then Western blot analysis was used to detect AIF levels in mitochondria and nucleus in hippocampus.Results Compared with control group,AIF levels were obviously decreased in the mitochondrial fraction while increased in the nuclear fraction in Ep 24 h group and Ep 72 h group(allP0.05).There were no significant differences of AIF levels in the mitochondrial fraction and the nuclear fraction in hippocampus between Ep 3 h group,Ep 8 h group and control group.Compared with Li-pilocarpine group,AIF levels were obviously increased in the mitochondrial fraction while decreased in the nuclear fraction in 3-AB group(allP0.05).There were no significant differences of AIF levels in the mitochondrial fraction and the nuclear fraction in hippocampus between Li-pilocarpine group and control group.Conclusion AIF level is increased in mitochondria and decreased in nucleus in hippocampus after seizures.In addition,PARP inhibition by 3-AB can suppress this changes." @default.
- W2367079680 created "2016-06-24" @default.
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- W2367079680 date "2010-01-01" @default.
- W2367079680 modified "2023-09-28" @default.
- W2367079680 title "Change of apoptosis induce factor level and influence of poly (adenosine diphosphate-ribose) polymerase inhibitor on it in epileptic rats" @default.
- W2367079680 hasPublicationYear "2010" @default.
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