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- W2367089555 abstract "Objective: To study the effects of polyphyllin Ⅱ(PPⅡ) on the growth of human bladder cancer in xenotransplanted model of BALB/c nude mice. Methods: Urothelial carcinoma of bladder cell lines T24 were cultured with or without PPⅡ. Cell proliferation was measured by MTT assay. The 50% inhibitory concentrations(IC50) of PPⅡ were calculated. Xenotransplanted model of T24 cells in nude mice was established and the mice were randomly divided into 4 groups: control group(n=10): with no treatments; normal saline group(n=10): 0.9% NS injected at dose of 5mg/kg once a week; PPⅡ group(n=10): polyphyllin Ⅱ injected at dose of 5mg/kg once a week; MMC group(n=10): mitomycin C injected at dose of 1.5mg/kg once a week. Six weeks after the treatment, tumor weight, size and growth inhibition rate were evaluated respectively. With the same treatment to the mice, the survivorship curves were drawn 60 days later. The expression of Bcl-2, cytochrome c, caspase-3, caspase-9 was detected by immunohistochemical staining. Results: The proliferation of T24 cells was significantly inhibited by PPⅡ. The 50% inhibitory concentrations(IC50) of PPⅡ were 8.011μmol/L, 4.148μmol/L, 3.012μmol/L at 24 h, 48 h and 72 h, respectively. Compared with the untreated controls, growth of the tumor implanted subcutaneously was significantly reduced in size in the mice treated with polyphyllin Ⅱ and MMC. Polyphyllin Ⅱ nearly had the same effect as MMC. Tumorsize in control, NS, PPⅡ groups and MMC groups were(1 530.83±37.93) mm3,(1 510.01±22.18) mm3,(37.83±14.91) mm3 and(23.28±11.62) mm3 respectively. The inhibition rate of PPⅡ was 70.32%, and that of MMC was 76.59%. The average survival time of PPⅡ group was(48.70±3.07) days. Extensive nucleus enrichment, nuclear fragmentation, cytoplasm area red dying were seen in PPⅡ group. The expression of cytochrome c increased after the treatment of PPⅡ. Conclusion: Polyphyllin Ⅱ can inhibit the growth of human bladder cancer in vivo and in vitro. It might effect the mitochondria apoptosis pathway and thus play a role in anti-bladder cancer." @default.
- W2367089555 created "2016-06-24" @default.
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- W2367089555 date "2014-01-01" @default.
- W2367089555 modified "2023-09-23" @default.
- W2367089555 title "Effects of polyphyllin II on nude mouse bearing human urothelial carcinoma of bladder" @default.
- W2367089555 hasPublicationYear "2014" @default.
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