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- W2367098241 abstract "Objective To investigate whether transcatheter closure of atrial septal defect makes cardiac troponin Ⅰ(cTnⅠ) realease in children.Methods Clinical data,laboratory tests,imagings,diagnosis,the information of interventional therapy and postoperative follow-up from 146 children with secundum atrial septal defect who were diagnosed and get treatment of interventional were collected.The median age was(5.87±3.48)years(range,2.25-12.5)with 87 boys and 59 girls.The device size ranged from 8 to 22 mm.These patients were divided to 2 groups according to the level of cTnⅠ after intervention.The cTnⅠ serum concentrations were examined immediately eafter intervention,6 hours later,24 hours later and 3 days after intervention.Results The level of cTnⅠ were normal before intervention,and the peak level of cTnⅠ was found at 6 hours after intervention(Z=-3.410,P=0.005).All of the patients had a normal level of cTnⅠ 3 days after operation(Z=-0.332,P=0.74).Univariate analysis showed age,height,device size,size/BSA ratio to be contributing factors for level of cTnⅠ.The device size/body surface area ratio was identified by demonstration positive correlation with cTnⅠ elevation by multivariate logistic regression analysis(r=0.31,P=0.022).Conclusions The transcatheter closure of atrial septal defect in children could lead to reversible increase of cTnⅠ or induce minor myocardial lesion,the extent of which depends on the ratio of device size/body surface area.Interventional therapy of atrial septal defect is safe and effective for children." @default.
- W2367098241 created "2016-06-24" @default.
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- W2367098241 date "2012-01-01" @default.
- W2367098241 modified "2023-09-28" @default.
- W2367098241 title "Research of cardiac troponin I release after transcatheter closure of atrial septal defect in children" @default.
- W2367098241 hasPublicationYear "2012" @default.
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