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- W2367103671 abstract "This study aims to clarify the effects of 8-week treadmill exercise on levels of appetite regulatory hormones in plasma and hypothalamus of obese rats.Diet-induced obese rats undergo long-term(40 min,5 days/week for 8 weeks) exercises.The rats run at a speed of 20m/min-1 on a treadmill specialized for them.Rats undergoing long-term exercise(LE) are compared to long-term control(LC).The rats' meal size and body weight are researched every day.Concentrations of ghrelin and obestatin are measured by RIA.Expression of ghrelin receptor(GHSR1a) and putative obestatin receptor(GPR-39) in the hypothalamus is measured by quantitative RT-PCR.In LE,their meal size decreases and body weight increases.But their increasing rate of body weight is not as great as LC.The levels of ghrelin and obestatin on plasma do not change.However,they decrease sharply on hypothalamus.GHSR-1a does not changed and GPR-39 is not found on hypothalamus.It concludes that appetite and body weight of obese rats are decreasing by exercise through reduced level of ghrelin in the hypothalamus.Obestatin-GPR39 seems to have no effect in exercise-induced change in appetite." @default.
- W2367103671 created "2016-06-24" @default.
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- W2367103671 date "2009-01-01" @default.
- W2367103671 modified "2023-09-26" @default.
- W2367103671 title "Influence of 8-Week Treadmill Exercise on Hypothalamic Ghrelin and Obestatin of Obese Rats" @default.
- W2367103671 hasPublicationYear "2009" @default.
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