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• W2367104427 startingPage "1492" @default.
• W2367104427 abstract "A portion of stage I/II colon cancers (10-20%) exhibit an adverse clinical course. The administration of adjuvant chemotherapy is recommended only in certain high-risk situations. However, these risk factors recently failed to predict benefit from adjuvant therapy. We composed a new morphology-based risk score that includes pT1/2 versus 3/4 stage, vascular or lymphovascular invasion, invasion type according to Jass, tumor budding and paucity (less than two) of lymph nodes larger than 5 mm. The occurrence of each of these factors accounts for one point in the score (Range 0-5). This score was evaluated in a retrospective study that included 301 cases. The overall survival differed significantly between the three groups with median survival times of 103, 90, and 48 months, respectively. Multivariable analysis revealed morphology-based risk-high risk and low risk-as the sole independent factors for the prediction of death. Morphology-based risk scoring was superior to microsatellite status and NCCN risk stratification. This method identifies a group of patients that comprises 18% of the stage II cases with an adverse clinical course. Further studies are necessary to confirm its prognostic value and the possible therapeutic consequences." @default.
• W2367104427 created "2016-06-24" @default.
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• W2367104427 date "2016-05-11" @default.
• W2367104427 modified "2023-10-02" @default.
• W2367104427 title "A new simple morphology-based risk score is prognostic in stage I/II colon cancers" @default.
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• W2367104427 doi "https://doi.org/10.1002/cam4.737" @default.
• W2367104427 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4867555" @default.
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• W2367104427 hasPublicationYear "2016" @default.
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