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- W2367107996 abstract "Kruppel-like factors(KLFs) are important components of the eukaryotic cellular transcription machinery.Their characteristic highly conserved carboxyl terminals contain three tandem Cys2His2 zinc fingers,which enable KLFs to bind to GC-and CACCC-boxes in DNA.CACCC box is a critical element in the promoter and enhancer regions of globin and erythroid transcription factor genes.Previous studies have shown that several KLFs play important roles in globin gene expression and erythroid differentiation through binding to CACCC box,for example,erythroid-specific transcription factor KLF1 activates β-globin gene expression,γ-to β-globin gene switching and erythroid differentiation through binding to β-globin gene promoter and locus control region(LCR);KLF2,KLF11 and KLF13 contribute to the expression of e-and γ-globin genes;and KLF4 activates the expression of α-and γ-globin genes,while KLF3 and KLF8 repress the expression of e-and γ-globin genes.Progress of KLFs' roles on globin expression and erythroid differentiation was reviewed in this article." @default.
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- W2367107996 date "2011-01-01" @default.
- W2367107996 modified "2023-09-26" @default.
- W2367107996 title "Regulation of KLFs on Globin Expression and Erythroid Differentiation" @default.
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