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- W2367113604 abstract "Objective:To improve the existing method for model-makeup of cirrhotic rats,to establish a stable method for model-makeup of cirrhotic rats and reduce the mortality rate in the process of molding in rats,and also to explore the liver cirrhosis rat model preparation with the infection of hepatitis B virus,and finally to provide a stable and reliable methods for the experimental animal models.Methods: 40 Wistar female rats were injected intraperitoneally olive oil solution with 50% CCl4 by the 0.4 ml/100g dose,and the injection were performed twice per week as well as they were weighted,meanwhile 10% ethanol was used as the only drinking provider source;When the weight were lower than or equal to 10 g or more,the delivery of injection was suspended,and the water provider was changed into normal drinking water;the mentioned program was continuously carried out again until the weight loss was less than 10g.Using 20 Wistar female rats,with the ratio of human hepatitis B virus serum to diluted normal saline solution as 1:20,were intraperitoneally injected weekly once; intragastric administration was performed twice per week with 30% ethanol,the drinking water and 10% ethanol were alternatively used as water resource,high-fat diet was normally provided.Results: The group with CCl4 olive oil: in the 40 Wistar rats there were 11 rats dead after 10 weeks,and 29 rats of them were developed into the modeling;the group with virus: one of 20 Wistar female rats was dead after 12 weeks,and the modeling was not established with this group.Conclusions: The improved methods of cirrhotic rats could enhance the successful rate of modeling makeup,and the cirrhoiss model of small nodules were formed through the conversion from chronic hepatitis;the viral cirrhosis rat model could be used as the control for the preparation of rats cirrhosis rat model in the future." @default.
- W2367113604 created "2016-06-24" @default.
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- W2367113604 date "2012-01-01" @default.
- W2367113604 modified "2023-09-23" @default.
- W2367113604 title "The liver cirrhosis modeling makeup was successfully improved by using oliver oil solution with CCl_4" @default.
- W2367113604 hasPublicationYear "2012" @default.
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