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- W2367119757 abstract "Objective To investigate the potential differential diagnosis role of Melan-A and Inhibin α in adrenal tumors. Methods 78 cases of formalin-fixed, paraffin-embedded tissue from 5 normal adrenal or adjacent tumor adrenal tissues, 17 adrenocortical adenomas, 8 primary adrenocortical carcinomas, 23 pheochromocytomas, 13 hepatocellular carcinomas and 12 renal cell carcinomas were prepared. The expession of Melan-A and Inhibin α antibodies were detected with PowerVision TM System immunohistochemical staining method. Results 5/5 (100%) normal adrenal or adjacent tumor adrenal tissues, 13 of 17 (76.5%) adrenal adenomas and 4 of 8 (50%) adrenal cortical carcinomas were reactive with Melan-A. The cytoplasmic reactivity for Melan-A in normal or adjacent tumor tissues, which showed granular in areas of zona glomerulosa, zona fasiculata and zona reticularis, was expressed, whereas the staining pattern in adrenal tumors was coarsely granular and most commonly in clear cell areas. 5/5 (100%) normal adrenal or adjacent tumor adrenal tissues, which expressed predominantly in zona reticularis and the internal layer of zona fasiculata showed cytoplasmic or membranous positive pattern for Inhibin α. The laternal layer of zona fasiculata, zona glomerulosa and adrenal medullary were negative for Inhibin α. 14 of 17 (82.4%) adrenal adenomas and 6 of 8 (75%) adrenal cortical carcinomas were reactive for Inhibin α, and the staining pattern was either cytoplasmic or membranous granular both in clear-cell and granular cell areas. None of the pheochromocytomas, hepatocellular carcinomas and renal cell carcinomas reacted with Melan-A. Moreover, all pheochromocytomas were also negative reaction for inhibin α. The expression of inhibin α in hepatocellular carcinoma and renal cell carcinoma was 23.1% and 16.7%, respectively. Conclusions Melan-A and Inhibin α are useful markers in differential diagnosis of adrenal tumors." @default.
- W2367119757 created "2016-06-24" @default.
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- W2367119757 date "2004-01-01" @default.
- W2367119757 modified "2023-09-28" @default.
- W2367119757 title "Role of Melan-A and Inhibin α in differential diagnosis of adrenal tumours" @default.
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