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- W2367133093 abstract "Objective To explore the change of soluble HLA-I molecules level in the treatment of chronic hepatitis B with entecavir and its implication.Methods CHB patients were randomly divided into three groups,treated with entecavir,diammonium glyrrihizinate and both of these two drugs (combined group) respectively. Soluble HLA-I molecules were detected by sandwich ELISA. Results After three-month treatment,the level of soluble HLA-I molecules in patients of entecavir group increased significantly. In patients of diammonium glyrrihizinate group,the level of soluble HLA-I molecules decreased significantly,and in patients of combined treatment group,the level of soluble HLA-I molecules remained unchanged. While after six-month treatment,the level of soluble HLA-I molecules in patients of all three groups decreased significantly compared to that before treatment. Conclusion The level of soluble HLA-I molecules may reflect the modulation of drugs on the patients′ immune function." @default.
- W2367133093 created "2016-06-24" @default.
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- W2367133093 date "2010-01-01" @default.
- W2367133093 modified "2023-09-24" @default.
- W2367133093 title "The change of soluble HLA class I molecules in the treatment of chronic hepatitis B with entecavir and its implication" @default.
- W2367133093 hasPublicationYear "2010" @default.
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