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- W2367142933 abstract "Objective To study the expression and significance of multidrug resistance gene(MDR1) in children with refractory epilepsy(RE).Methods Children with RE(n = 30),non-RE(n = 30) and healthy children(n=30) were collected.The expression of MDR1-mRNA in peripheral blood was analyzed by fluorescence quantitative PCR.The re-lationship of MDR1-mRNA with epileptic frequency and numbers of antiepileptic drugs(AEDs) were observed.Results The expression of MDR1 in RE group obviously increased when compared with that of non-RE group and healthy group(P 0.01,P 0.01);MDR1 expression was more among patients with high frequent epilepsy than patients with low frequent epilepsy(P 0.01);more in patients administered with four kinds of AEDs than those with two or three kinds of AEDs(P 0.01).Conclusions MDR1 overexpression in blood of children with RE may be linked to drug-resistant mechanism of RE.It might be used as a clinical indicator of RE." @default.
- W2367142933 created "2016-06-24" @default.
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- W2367142933 date "2009-01-01" @default.
- W2367142933 modified "2023-09-27" @default.
- W2367142933 title "The expression and significance of multidrug resistance gene in children with refractory epilepsy" @default.
- W2367142933 hasPublicationYear "2009" @default.
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