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- W2367145890 abstract "Objective To investigate the changes of inducible nitric oxide synthase (iNOS) activity in neonatal rat cardiac fibroblasts(CFs) induced by aldosterone.Methods The CFs of neonatal SD rats were cultured isolated by trypsin digestion method,MTT colorimetric assay was adopted to evaluate cell proliferation while nitric acid reductase method,spectrophotometry and reverse transcription-polymerase chain reaction were used to detect the NO contents,iNOS activity and c-fos mRNA expression respectively at different concentrations of aldosterone.Results Aldosterone (10-11-10-7mol/L) increased the proliferation of the CFs and c-fos mRNA expression but decreased the NO contents and iNOS activity in a dose-depend manner(P0.05).In a significant way CFs proliferation was significant negatively correlated with NO contents and iNOS activity,which was induced by different concentrations of aldosterone (r=-0.942,-0.978,respectively,P0.01).Conclusion Aldosterone decreases iNOS-NO system activity in neonatal rat CFs,and stimulates the proliferation of CFs." @default.
- W2367145890 created "2016-06-24" @default.
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- W2367145890 date "2010-01-01" @default.
- W2367145890 modified "2023-09-24" @default.
- W2367145890 title "Effects of Aldosterone on Activity of iNOS-NO System in Neonatal Rat Cardiac Fibroblasts" @default.
- W2367145890 hasPublicationYear "2010" @default.
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