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- W2367156612 abstract "Objective: To study the correlation of the expression of Smad4 and TGF-β receptor Ⅱ(TβR-Ⅱ) with clinical pathology in cervical adenocarcinoma,and to explore its possibility as a marker to decide the prognosis of cervical adenocarcinoma.Methods: To detect the expression of Smad4 and TβR-Ⅱin 36 cases of cervical adenocarcinoma and 20 cases of normal cervical glandular epithelium tissue and to investigate the relation between the expression of Smad4 with TβR-Ⅱand clinical pathology. Results: The expression of Smad4 and TβR-Ⅱin cervical adenocarcinoma is significantly lower than normal cervical glandular epithelium tissue(P0.05).The expression of Smad4 and TβR-Ⅱin cervical adenocarcinoma with poor differentiated was significantly lower than that of moderate or well differentiated(P0.05).The expression of Smad4 and TβR-Ⅱis significantly lower in cervical adenocarcinoma with metastatic lymph nodes than in the tissue with no metastatic lymph nodes(P0.05).The expression of Smad4 and TβR-Ⅱ was significantly related with clinical stage(P0.05). Conclusion: The deleted expression of Smad4 and TβR-Ⅱ was associated with development,advanced,differentiated and metastasis in cervical adenocarcinoma.Smad4 and TβR-Ⅱmay be a marker for differentiated and metastasis of cervical adenocarcinoma.To detect Smad4 and TβR-Ⅱmay be a useful tumor marker to decide the prognosis of cervical adenocarcinoma." @default.
- W2367156612 created "2016-06-24" @default.
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- W2367156612 date "2009-01-01" @default.
- W2367156612 modified "2023-09-23" @default.
- W2367156612 title "Expression and significance of Smad4 and TGF-β receptor II in cervical adenocarcinoma" @default.
- W2367156612 hasPublicationYear "2009" @default.
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