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- W2367156989 abstract "Objective To establish the adjusted value for multiple of the median(MOM) of a disintegrin and metalloprotease 12-secreting-type(ADAM12-S) in prenatal serum screening for Down′s syndrome.Methods The parturients,who were voluntary participants of prenatal screening program for Down′s syndrome during 2008 and were confirmed to labor healthy newborn by follow-up visit,were randomly enrolled in this study.Totally 577 serum samples of the first trimester(from 8 to 13 weeks) were collected and the concentration of ADAM12-S was determined by time-resolved fluorimmunoassay(TRFIA).The regressive relationship between concentration of ADAM12-S and gestational age was analyzed with SPSS 15.0 software and then the optimal model was selected for the calculation of MOM value of ADAM12-S.The MOM value was adjusted on the basis of the body weight of parturients.The curve fitting of ADAM12-S concentration and the adjusted MOM value were conducted and the model was optimized for the equation by eliminating the influence of gestational age and body weight.Results A positive correlation between the MOM value of ADAM12-S(Y) and gestational age(t) was shown,and the equation was Y=e8.412-24.534/t,while a negative correlation between MOM value of ADAM12-S(Y) and body weight of parturients(z) was found,and the equation was Y=1.603*e-0.009*z.The equation of concentration of ADAM12-S(Y) and the adjusted MOM value(X) was Y=0.036*X0.552.Conclusions The equation between the initial concentration of ADAM12-S and the adjusted MOM value was established.It should be considerably important for the screening program of Down′s syndrome in primary clinical hospital for newborn." @default.
- W2367156989 created "2016-06-24" @default.
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- W2367156989 date "2011-01-01" @default.
- W2367156989 modified "2023-09-23" @default.
- W2367156989 title "Establishment of adjusted value for multiple of median of ADAM12-S concentration in prenatal serum screening during early pregnancy" @default.
- W2367156989 hasPublicationYear "2011" @default.
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