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- W2367158930 abstract "Objective To investigate the feasibility of diffusion weighted imaging(DWI)at clinic 1.5T scanner in vivo in a xenotransplant nude mouse model with human colon carcinoma.Methods The tumor pieces of human colon cancer SW480 were implanted subcutaneously in 25 nude mice.These mice were scanned to acquire TSE-T2WI and EPI-DWI.MR images were correlated with histopathological findings.Results All tumors were detected clearly on T2WI images,and shown as hyper-intensity and more hyper-intensity in necrotic areas.Tumor lesions on images of DWI were easier discerned with increasing b value,more similar to T2WI.All tumor can be discerned clearly on b≥800 s/mm2 ADC images and b≥700 s/mm2 EADC images.ADC value in necrotic area was significantly higher and EADC value significantly lower than in no-necrostic area.Conclusion A xenotransplant nude mouse model with human colon carcinoma can be investigated with MRI-DWI at a clinic 1.5T scanner.MR images correlated well with pathology findings,and may be advantages for easier extrapolation of the result to clinical human studies." @default.
- W2367158930 created "2016-06-24" @default.
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- W2367158930 date "2009-01-01" @default.
- W2367158930 modified "2023-09-25" @default.
- W2367158930 title "DWI in human colonic neoplasms nude-mice transplanted tumor models by clinic 1.5T MR scanner" @default.
- W2367158930 hasPublicationYear "2009" @default.
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