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- W2367175273 abstract "OBJECTIVE: To evaluate the antitumor effect of hirudin on H22 tumor cells in mice.METHODS: 40 mice were injected with H22 hepatoma cells from their right axillae to establish solid tumor model before being randomly divided into 4 groups of 10 each: high dose hirudin group,and low dose hirudin group,5-FU group and model control group.The body weight and survival of mice in all groups were recorded.After exposing to medications for 14 days,the tumors were taken out and weighted with tumor inhibition rate,liver/body ratio,kidney/body ratio and spleen indices computed and body weight before and after medication recorded.RESULTS: Hirudin at either high dose or low dose significantly inhibited H22 tumor cells in mice,with tumor inhibition rates of 37.63% and 23.71%,respectively,showing significant differences compared to model control group(P0.01,P0.05).The high dose hirudin group and low dose hirudin group differed greatly from 5-FU group with regard to liver/body ratio,kidney/body ratio and spleen indices(P0.05).Weight change of the hirudin groups(high dose or low dose) was not significant as compared with before treatment or compared with the model control group(P0.05).CONCLUSION: Hirudin has significant antitumor effect on H22 tumor cells and protective effect on vital organs in mice." @default.
- W2367175273 created "2016-06-24" @default.
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- W2367175273 date "2011-01-01" @default.
- W2367175273 modified "2023-09-25" @default.
- W2367175273 title "Antitumor Effect of Hirudin in Mice Bearing H22 Hepatocellular Carcinoma" @default.
- W2367175273 hasPublicationYear "2011" @default.
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