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- W2367196422 abstract "OBJECTIVE Evaluate effect of rifabutin on itself metabolism and some main CYP450 isoenzymes in subcelluar,organic and in vivo studies for guiding drugs administration in clinical.METHODS 36 Rats were divided into 6 groups at random,n=6 in every group.There were the control group and the rifabutin taken group(300 mg·kg-1,po,7 d) in 3 different kinds of studies.In the subcellular studies,we incubated the specific substrates using the prepared microsome,and then compared the form rate of their metabolites to evaluate the main isoform activity,such as CYP1A2,CYP2D6,CYP2C9,CYP2E1 and CYP3A.The liver perfusion and jugular intubatton(blood was sampled in different time next day)were applied in the organic studies and in vivo studies respectively,and then compared the metabolism parameters of rifabutin.RESULTS Protein concentration and the enzyme activities turned to 84.60% and 410.0% comparing the control group respectively.CYP3A and CYP2D6 activities turn to 84.00% and 155.7% comparing the control group,respectively.The metabolism of rifabutin was enhanced in rifabutin taken group both organic and in vivo studies.t1/2 were turned to 58.96% and 71.00% respectively and AUC was turned to 49.06% comparing the control group in organic level.CONCLUSION There was autoinduction in the metabolism of rifabutin.The metabolism of not only rifabutin itself but also those drugs metabolized by CYP3A or CYP2D6 would be increased after pretreatment of rifabutin." @default.
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- W2367196422 date "2007-01-01" @default.
- W2367196422 modified "2023-09-22" @default.
- W2367196422 title "Studies on Metabolism of Rifabutin" @default.
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