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- W2367202517 abstract "Objective: To optimize formula of gastric floating tablets of total glucosides from Centella asiatica.Method: Gastric floating tablets were prepared by direct compression with dry powder.With floating properties and in vitro release as indexes,single factor tests and mixture design test were adopted to optimize formulation parameters which impacted properties of gastric floating tablets of total glucosides from C.asiatica.Result: Optimum formulation included 25% total glucosides from C.asiatica,28.6% HPMC K15M,15.6% NaHCO3,20.8%CMS-Na and 10%PEG20000.The results showed that these products could float within(3.2 ± 0.2) min and maintain for over 12 h,in vitro release of this tablets fitted zero-order kinetics model.Conclusion: These prepared gastric floating tablets showed a good sustained-release and continual floating property.it could increase residence time and improve efficacy for gastric ulcer." @default.
- W2367202517 created "2016-06-24" @default.
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- W2367202517 date "2013-01-01" @default.
- W2367202517 modified "2023-09-28" @default.
- W2367202517 title "Optimization of Formulation Technology for Gastric Floating Tablets of Total Glucosides from Centella asiatica" @default.
- W2367202517 hasPublicationYear "2013" @default.
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