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- W2367218909 abstract "The intensity and severity of perceived pain does not always correlate linearly with the degree of tissue damage or injury or with the intensity of nociceptive activity. In this respect, the importance of context and the modulation of pain by emotion is now widely recognised. In particular, stress, fear and anxiety exert potent, but complex, modulatory influences on pain. Depending on the nature, duration and intensity of the stressor, stress can either suppress pain (stress-induced analgesia; SIA) or exacerbate it (stress-induced hyperalgesia; SIH). This chapter reviews the methods and models used to study these two phenomena in rodents and humans and then presents detailed discussion of our current understanding of the neural substrates and neurobiological mechanisms involved. Concepts of cognitive modulation of pain, including the influence of attention and distraction-induced analgesia (DIA), are also introduced in the context of their relevance to the modulation of pain by stress and emotion. The chapter concludes with some perspectives on the implications and complications that emotional and cognitive factors present for the current and future treatment of pain and its comorbidity with stress-related psychiatric disorders including anxiety and depression." @default.
- W2367218909 created "2016-06-24" @default.
- W2367218909 creator A5002112371 @default.
- W2367218909 date "2013-01-01" @default.
- W2367218909 modified "2023-09-27" @default.
- W2367218909 title "CHAPTER 10. Pain Management Companies" @default.
- W2367218909 doi "https://doi.org/10.1039/9781849737715-00309" @default.
- W2367218909 hasPublicationYear "2013" @default.
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