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- W2367219907 abstract "Objective To study the feasibility of target controlled infusion (Marsh mode) of propofol in pediatric anesthesia induction.Methods Thirty children were scheduled for abdominal surgery or urinary surgery, with the age of 3 to 11 years. The initial target plasma concentration of propofol was 3 μg/ml, and then was increased by 0.5 μg/ml every 2 minutes until bispectral index (BIS) droped to 50. After BIS reached 50 for 2 minutes, endotracheal intubation was performed. In whole induction, patients breathed spontaneously with 100% oxygen via a facemask. Systolic blood pressure (SBP), heart rate (HR), pulse oxygen saturation (SpO2), and respiratory frequency (RR) were recorded before induction, when children were unconsciousness, and when BIS was 50. Before endotracheal intubation, 1 ml of blood was obtained from radial artery to determine the plasma concentration of propofol.Results Compared with pre-induction, SBP and HR decreased when children were unconsciousness and BIS was 50 (P0.05). The reduced percents of SBP and HR were (7.55±2.50)% and (16.90±4.10)%, respectively. Correlation analysis indicated that CRT and Cp were positive correlated with the correlation coefficient of 0.781. Conclusion The Marsh mode of target-controlled infusion of propofol is effective for pediatric anesthesia induction." @default.
- W2367219907 created "2016-06-24" @default.
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- W2367219907 date "2012-01-01" @default.
- W2367219907 modified "2023-09-26" @default.
- W2367219907 title "Application of target controlled infusion of propofol in pediatric anesthesia induction" @default.
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