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- W2367225806 abstract "Objective:To discuss the effect of Qinggan Huoxue recipe on intestinal tight junction ZO-1 protein,and to identify the target which Qinggan Huoxue recipe interfere in the Gut-derived endotoxin translocation .Methods:Caco-2 cell model was applied,the model of enterocyte was made,the dose and time of ethanol effect was screened,and the effect of this recipe on Caco-2 cell expressing ZO-1 protein was detected by Western blot.Results:Low concentration ethanol had significantly increased the permeability of Caco-2 cell model,while reduced ZO-1 protein expression;Qinggan Huoxue recipe could improve ZO-1 protein expression,shown a certain dose-effect relationship.Qinggan Huoxue recipe could improve cell permeability by regulating ZO-1 protein expression.Conclusion:Qinggan Huoxue recipe can improve Caco-2 cell permeability caused by ethanol through regulating ZO-1 protein expression." @default.
- W2367225806 created "2016-06-24" @default.
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- W2367225806 date "2008-01-01" @default.
- W2367225806 modified "2023-09-23" @default.
- W2367225806 title "Effect of Qinggan Huoxue recipe on intestinal epithelial cells tight junction related protein ZO-1" @default.
- W2367225806 hasPublicationYear "2008" @default.
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