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- W2367226739 abstract "Objective:To observe the effect of utility monomer in Kangxianling to the renal fibroblast cell line and mesangial cell line.Methods:Adopt the method of culturing the renal fibroblast cell line and mesangial cell line in vitro,which were divided into blank control group,TGF-β_1 2ng/mL group,TGF-β_1 2ng/mL+Chinese medicine monomer 10~(-5)g/mL group and TGF-β_1 2ng/mL +Chinese medicine monomer 10~(-6)g/mL group.Observing the effect of Chinese medicine monomer for 24 hours to the two cell lines by MTT assay,and the secretion of TGF-βby ELISA assay.Results:Compared with blank control group,adding TGF-β_1-stimulating factor could promote the two cell lines(P0.05),as well as the secretion of TGF-β(P0.01),Chinese medicine monomer could inhibit the activation of two cell lines proliferation and secretion of TGF-β(P0.05,P0.01).Conclusion:Utility monomer of Kangxianling can inhibit the activation of the renal fibroblast cell line and mesangial cell line proliferation and secretion of TGF-β,effectively prevent and treat renal fibrosis,and its possible mechanism of action is related to inhibition of TGF-βsecretion." @default.
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- W2367226739 date "2013-01-01" @default.
- W2367226739 modified "2023-09-28" @default.
- W2367226739 title "Effects of utility monomer in Kangxianling to the renal fibroblast cell line and mesangial cell line" @default.
- W2367226739 hasPublicationYear "2013" @default.
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