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- W2367237080 abstract "Objective To investigate the blood_pressure lowering mechanism of Bushen Yixin Tablet(BYT)and its protective effect on the heart, brain and kidney and other target organs in renal hypertension rat model. Methods Goldblatt's hypertension rat model was established by occlusion of the left renal artery. All rats were allocated to BYT groups (with high,moderate and low dosages respectively, Group A,Group B and Group C respectively),captopril group(Group D), model group(Group E) and mimic operation group(Group F). After 4 weeks of treatment, tail arterial pressure was measured,plasma NO level and platelet aggregation rate were detected and the pathologic changes of heart, brain and kidney were observed. Diuretic effect of BYT was also studied. Results In BYT groups and Group D,blood pressure was decreased,NO synthesis enhanced,platelet aggregation rate lowered and the damage of target organs markedly alleviated as compared with Group E(P 0.05 orP 0.01 ).BYT had mild diuretic effect, which is weaker than that of dihydrochlorothiazide(Group G) (P 0.01 ). Conclusion The blood_pressure lowering mechanism of BYT may be related to the enhancement of NO synthesis and diuretic effect and inhibition of platelet aggregation. BYT can also protect the heart, brain and kidney and other target organs from hypertension_induced damage." @default.
- W2367237080 created "2016-06-24" @default.
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- W2367237080 date "2001-01-01" @default.
- W2367237080 modified "2023-09-25" @default.
- W2367237080 title "Blood_Pressure Lowering and Target-Organ Protective Effects of Bushen Yixin Tablet on Rats with Renal Hypertension" @default.
- W2367237080 hasPublicationYear "2001" @default.
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