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• W2367244125 abstract "Rationale: Proton pump inhibitors (PPIs) are popular drugs for gastroesophageal reflux, which are now available for long-term use without medical supervision. Recent reports suggest that PPI use is associated with cardiovascular, renal, and neurological morbidity. Objective: To study the long-term effect of PPIs on endothelial dysfunction and senescence and investigate the mechanism involved in PPI-induced vascular dysfunction. Methods and Results: Chronic exposure to PPIs impaired endothelial function and accelerated human endothelial senescence by reducing telomere length. Conclusions: Our data may provide a unifying mechanism for the association of PPI use with increased risk of cardiovascular, renal, and neurological morbidity and mortality." @default.
• W2367244125 created "2016-06-24" @default.
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• W2367244125 date "2016-06-10" @default.
• W2367244125 modified "2023-10-14" @default.
• W2367244125 title "Proton Pump Inhibitors Accelerate Endothelial Senescence" @default.
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• W2367244125 doi "https://doi.org/10.1161/circresaha.116.308807" @default.
• W2367244125 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4902745" @default.
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