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- W2367262016 abstract "Objective To investigate the effect of C3 exoenzymea,specific Ras homolog gene family member A(RhoA)inhibitoro,n bradykinin(BK)-induced increase in blood-tumor barrier(BTB)permeability.Methods Rat brain microvascular endothelail cells(RB-MECs)were pretreated with C3 exoenzyme and then treated with BK for 15 minutes.Horseradish peroxidase(HRP)flux and TEER assays were employed to reveal BTB permeability.The protein expression level of ZO-1 was observed by Western blot.The stress fiber formation and distribution of filamentous actin(F-actin)and ZO-1 were assessed by immunofluorescence microscopy.Results C3 exoenzyme could par-tially inhibit endothelial leakage and restored normal TEER values in RBMECs.The expression level of ZO-1 protein decreased significantly and it was prevented by C3 exoenzyme.C3 exoenzyme inhibited BK-induced relocation of ZO-1 from cellular borders into the cytoplasm as well as stress fiber formation in RBMECs.Conclusion RhoA plays a key role in BK-induced openning of blood-tumor barrier." @default.
- W2367262016 created "2016-06-24" @default.
- W2367262016 creator A5081344725 @default.
- W2367262016 date "2011-01-01" @default.
- W2367262016 modified "2023-09-27" @default.
- W2367262016 title "C_3 Exoenzyme Inhibits Bradykinin-induced Selective Increase of the Permeability of Blood-tumor Barrier" @default.
- W2367262016 hasPublicationYear "2011" @default.
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