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- W2367267005 abstract "OBJECTIVE:To investigate the effect of olaquindox on the antioxidant system in human hepatoma G2(HepG2) cells. METHODS: HepG2 cells were treated with 0,200,400 and 800 μg/ml olaquindox in 24 h. The activities of superoxide dismutase(SOD) and catalase(CAT),the level of malondialdehyde(MDA),the activities of glutathione (GSH) and glutathione peroxidase (GSH-PX),Na+K+-ATPase and Ca2+Mg2+-ATPase were measured. SOD or CAT,and the combination of SOD+CAT were incubated for 3 h with olaquindox-treated HepG2 cells. The levels of reactive oxygen species (ROS) were evaluated by 2,7-dichlorodihydrofluorescein diacetate(DCFDA). RESULTS: Olaquindox decreased the levels of T-ATPase,Na+K+-ATPase and Ca2+Mg2+-ATPase,SOD,GSH ,GSH-PX,in HepG2 cells(P0.05 or P0.01),with a dose-response relationship. After HepG2 cells were treated with olaquindox,the activity of CAT was decreased when compared with the control(P0.01). Olaquindox led to a dose-dependent increase in the level of MDA(P0.05 or P0.01). While HepG2 cells were treated with olaquindox (800 μg/ml),CAT,SOD and SOD+CAT reduced ROS about 80% ,40%and 95%,respectively(P0.01). CONCLUSION: Olaquindox disrupted the antioxidant system in HepG2 cells. Our results indicated that olaquindox-induced HepG2 cells predominantly generated H2O2,which could be scavenged by CAT." @default.
- W2367267005 created "2016-06-24" @default.
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- W2367267005 date "2010-01-01" @default.
- W2367267005 modified "2023-09-23" @default.
- W2367267005 title "Olaquindox weakened the antioxidant system in human hepatoma G2 cells" @default.
- W2367267005 hasPublicationYear "2010" @default.
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