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- W2367294419 abstract "OBJECTIVE:To study the protective effects of Carthamus tinctorius injection on peripheral nerve ischemia-reperfusion(IR) injury in rats and its mechanism.METHODS:The test were randomly divided into six groups,i.e.control group(constant volume normal saline),model group(constant volume normal saline),mannite group(5 mL·kg-1),C.tinctorius injection high-dose,medium-dose and low-dose groups(32,16,8 mL·kg-1) with intravenous administration.Peripheral nerve IR model was established by clamping common iliac artery,internal iliac artery and external iliac artery for 6 h.The limb function and neural electrophysiology of rats were tested.The levels of super oxide dismutase(SOD),malonaldehyde(MDA),calcium and tumor necrosis factor-α(TNF-α) in nervi ischiadicus tissue were detected.RESULTS:Compared with model group,the limb function and MDA of C.tinctorius injection medium-dose and high-dose groups were decreased significantly while the activity of SOD increased significantly(P0.01,P0.05);In C.tinctorius injection high-dose group,TNF-α and latent period were decreased significantly,but conduction velocity and amplitude were increased obviously(P0.01,P0.05).CONCLUSION:C.tinctorius injection has a protective effect for peripheral nerve IR injury in experimental rat,which may be related to the inhibition of oxidative stress,calcium overloading and inflammation." @default.
- W2367294419 created "2016-06-24" @default.
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- W2367294419 date "2011-01-01" @default.
- W2367294419 modified "2023-09-23" @default.
- W2367294419 title "Protective Effects of Carthamus tinctorius Injection on Peripheral Nerve Ischemia-reperfusion Injury in Rats and Its mechanism" @default.
- W2367294419 hasPublicationYear "2011" @default.
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