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- W2367297002 abstract "Aim To study the hydrating and swelling properties of Carbopol 934p and its effect on tranilast release from Carbopol matrices.Methods Tablet press method was used to obtain the tranilast sustained release(SR) tablet matrices consisting of Carbopol 934p and small amounts of other excipients and the pure excipient tablets.These tablets were soaked in stimulated intestinal fluid(SIF,pH7.3) and stimulated gastric fluid(SGF,pH1.3) respectively and the weights and dimensions were measured using a gravimetric method and by a micrometer screw gauge during the hydrating and swelling process of the tablets.Results For pure excipient tablets,the hydrating rates were 1.053h -1 in SGF and 2.756h -1 in SIF;the swelling rates were 1.033h -1 in SGF and 2.451h -1 in SIF;at 5 hours the swelled volumes were 5.87 times larger in SGF and 13.0 times larger in SIF than the original volumes for tranilast SR tablets;the weight and dimension increased quickly at the first half hour in SGF and then remained constant;as in SIF,it increased slowly with the prolongation of the immersion within 5 hours and then its dimension remained constant.The extensions of dissolution of tranilast from the SR matrix tablets,to their perfect extent were 0.72%(in SGF),94.3%(in SIF) and 98.7%(in gradient pH) within 10 hours.Conclusion The extent and velocity of hydrating and swelling of matrix were affected by the pH of the dissolution medium and the time of immersion,and the swelling of Carbopol 934p is a rate limiting factor of tranilast release from the matrix." @default.
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- W2367297002 date "2000-01-01" @default.
- W2367297002 modified "2023-09-28" @default.
- W2367297002 title "Study on the Hydrating and Swelling Properties of Carbopol 934p and Its Effect on Tranilast Release from the Matrices in Vitro" @default.
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