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- W2367315352 abstract "Objective To study the possible protective mechanisms of Anisodamine against liver injury induced by hemorrhage shock(HS). Methods In this study, we established animal models induced by HS and endotoxin, observed the expressions of NF-κB mRNA and heat shock protein 70(HSP 70) mRNA by In-situ hybridization (ISH) in liver kupffercells(KC) and studied the pathologic changes of the liver tissue by microscope. Results After stimulus of HS and injection of endotoxin, the mRNA expressions of HSP70 and NF-κB in KC were (0.1565±0.0260) and (0.1659±0.0103),respectively, and significantly higher than those in the control group (0.0328±0.0201; 0.0256±0.0043)(P0.01). Anisodamine could significantly enhance the expression of HSP70mRNA (0.2019±0.0396), suppress the expression of NF-κB mRNA (0.1276±0.0083)(P0.01), and alleviate the damage of liver tissue. Conclusion By enhancing the expression of HSP70, anisodamine suppresses the activation of NF-κB and therefore plays a protective role against the liver injury induced by HS." @default.
- W2367315352 created "2016-06-24" @default.
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- W2367315352 date "2005-01-01" @default.
- W2367315352 modified "2023-09-24" @default.
- W2367315352 title "Protective Role of Anisodamine Against Rabbit Liver Injury by Hemorrhage Shock Complicated with Endotoxemia and the Underlying Mechanism" @default.
- W2367315352 hasPublicationYear "2005" @default.
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