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- W2367330246 abstract "Objective To study the effect of TNF-α antagonist (rhTNFR-Fc) treatment on the peripheral T cell proliferation of ankylosing spondylitis (AS) patients. Methods Peripheral blood mononuclear cells (PBMC) were collected from 10 patients with AS at baseline, after the first, and forth injection and from 13 healthy controls. CD4+ T cell proliferation after stimulation were assayed with WST-1 live cell staining method. And its correlation with the clinical parameters was analyzed. Rusults The proliferation rate of CD4+ T cells at the baseline was higher than that in the healthy control(P value were respectively 0.0034). Compareing to the baseline there was no significant change. ②The change of the proliferation rate of CD4+ T cells were all negative value. ③No correlation was found between the proliferation rate of CD4+ T cells and clinical parameters. Conclusion AS patients had a up regulation of the ability of T cells proliferation. The treatment with rhTNFR-Fc in active AS induced a reduction of CD4+ T cell proliferation." @default.
- W2367330246 created "2016-06-24" @default.
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- W2367330246 date "2008-01-01" @default.
- W2367330246 modified "2023-09-26" @default.
- W2367330246 title "The study of the mechanism on peripheral T cells proliferation function in AS patients treated with TNF-α blocker" @default.
- W2367330246 hasPublicationYear "2008" @default.
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