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• W236733732 abstract "Research Article1 December 1992free access IL-4 activates a distinct signal transduction cascade from IL-3 in factor-dependent myeloid cells. L.M. Wang L.M. Wang Laboratory of Cellular and Molecular Biology, NCI, NIH, Bethesda, MD. Search for more papers by this author A.D. Keegan A.D. Keegan Laboratory of Cellular and Molecular Biology, NCI, NIH, Bethesda, MD. Search for more papers by this author W.E. Paul W.E. Paul Laboratory of Cellular and Molecular Biology, NCI, NIH, Bethesda, MD. Search for more papers by this author M.A. Heidaran M.A. Heidaran Laboratory of Cellular and Molecular Biology, NCI, NIH, Bethesda, MD. Search for more papers by this author J.S. Gutkind J.S. Gutkind Laboratory of Cellular and Molecular Biology, NCI, NIH, Bethesda, MD. Search for more papers by this author J.H. Pierce J.H. Pierce Laboratory of Cellular and Molecular Biology, NCI, NIH, Bethesda, MD. Search for more papers by this author L.M. Wang L.M. Wang Laboratory of Cellular and Molecular Biology, NCI, NIH, Bethesda, MD. Search for more papers by this author A.D. Keegan A.D. Keegan Laboratory of Cellular and Molecular Biology, NCI, NIH, Bethesda, MD. Search for more papers by this author W.E. Paul W.E. Paul Laboratory of Cellular and Molecular Biology, NCI, NIH, Bethesda, MD. Search for more papers by this author M.A. Heidaran M.A. Heidaran Laboratory of Cellular and Molecular Biology, NCI, NIH, Bethesda, MD. Search for more papers by this author J.S. Gutkind J.S. Gutkind Laboratory of Cellular and Molecular Biology, NCI, NIH, Bethesda, MD. Search for more papers by this author J.H. Pierce J.H. Pierce Laboratory of Cellular and Molecular Biology, NCI, NIH, Bethesda, MD. Search for more papers by this author Author Information L.M. Wang1, A.D. Keegan1, W.E. Paul1, M.A. Heidaran1, J.S. Gutkind1 and J.H. Pierce1 1Laboratory of Cellular and Molecular Biology, NCI, NIH, Bethesda, MD. The EMBO Journal (1992)11:4899-4908https://doi.org/10.1002/j.1460-2075.1992.tb05596.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Interleukin-4 (IL-4) was shown to induce a potent mitogenic response in the IL-3-dependent myeloid progenitor cell line, FDCP-2. Although IL-4 could not sustain long-term growth of FDCP-2 cells, it enhanced their growth in serum-free medium containing IL-3. IL-4 triggered prominent tyrosine phosphorylation of a substrate(s) migrating at 170 kDa and less striking phosphorylation of several other proteins, including the IL-4 receptor. By contrast, IL-3 induced distinct tyrosine phosphorylation of proteins migrating at 145, 97, 70, 55 and 52 kDa in the same cell line. IL-4 treatment of FDCP-2 cells caused a dramatically strong association of phosphatidylinositol 3-kinase (PI 3-kinase) both with the 170 kDa tyrosine phosphorylated substrate and with the IL-4 receptor itself. By contrast, IL-3 triggered only weak association of PI 3-kinase activity with the 97 kDa substrate. While IL-4 did not affect cellular raf, IL-3 stimulation did induce a shift in its mobility presumably due to serine/threonine phosphorylation. Taken together, our results indicate that IL-4 and IL-3 activate distinct phosphorylation cascades in the same cell background; this may reflect a difference in the biological function of these two cytokines. Previous ArticleNext Article Volume 11Issue 131 December 1992In this issue RelatedDetailsLoading ..." @default.
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• W236733732 date "1992-12-01" @default.
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• W236733732 title "IL-4 activates a distinct signal transduction cascade from IL-3 in factor-dependent myeloid cells." @default.
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• W236733732 doi "https://doi.org/10.1002/j.1460-2075.1992.tb05596.x" @default.
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