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- W23673511 abstract "Publisher Summary This chapter presents the basic pharmacology as well as the use of heparin (HP) and low molecular weight HPs in clinical cardiology. A specific pentasaccharide sequence in unfractionated heparin (UH) is the traditional anticoagulant agent used in various conditions, such as deep vein thrombosis and acute coronary syndromes (ACS). UH is heterogeneous with respect to molecular size, anticoagulant activity, and pharmacokinetic properties. Its molecular weight ranges from 3,000 to 30,000 Da with a mean molecular weight of 15,000 Da. The chain length of the molecules influences the anticoagulant profile and clearance of UH, with the higher molecular weight species cleared from the circulation more rapidly than the lower molecular weight species. The complex pharmacokinetics of UH are because of its nonspecific binding to many plasma proteins and to vascular and blood cells. UH is poorly absorbed from the gastrointestinal tract and therefore, must be administered parenterally. UH has some important pharmacokinetic, biophysical, and biological limitations. Low molecular weight heparins (LMWHs) overcome the pharmacokinetic and some of the biological limitations of UF, but they share the same biophysical limitations." @default.
- W23673511 created "2016-06-24" @default.
- W23673511 creator A5059024903 @default.
- W23673511 date "2005-01-01" @default.
- W23673511 modified "2023-10-17" @default.
- W23673511 title "Heparin and Low Molecular Weight Heparins in Clinical Cardiology" @default.
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