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- W2367366948 abstract "Objective To investigate the changes of caspase-1 expression and its enzymatic activ- ity during acute renal ischemia-reperfusion injury. Methods Mice model of acute renal ischemia-reperfusion injury was established. Serum creatinin (Scr) and blood urea nitrogen (BUN) were measured by an auto- analyzer. Caspase-1 expressed in renal tissue was detected by immunohistochemistry, and the enzymatic activity of caspase-1 was measured by a fluorescent microplate reader. Results Scr and BUN were increased significantly in the group of acute renal ischemia-reperfusion injury as compared with those in the control group treated with sham operation. Caspase-1 expression and its activity in renal tissue were also much higher in acute renal ischemia-reperfusion injury model than in the controls. Conclusion The over expression and activation of caspase-1 in renal tissue may play an important role in the pathogenesis of acute renal ischemic- reperfusion injury. Control of the hyperactive downstream cytokine network through the inhibition of caspase-1 activity may be a new strategy for the therapy of acute renal ischemia-reperfusion injury." @default.
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- W2367366948 date "2007-01-01" @default.
- W2367366948 modified "2023-09-23" @default.
- W2367366948 title "Expression of caspase-1 and its enzymatic activity in acute ischemia-reperfusion injured kidney in mice" @default.
- W2367366948 hasPublicationYear "2007" @default.
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