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- W2367372457 abstract "Objective:The current study was designed to cla rify whether hepatopoietin(HPO)stimulates autonomous growth of hepatoma cell b y autocrine loop.Methods :The authors conducted experiments i n vitro with hepatoma cell lines.RT-PCR,ELISA a nd Western blot were used to examine H PO expression in hepatoma cells.Blocking effect of HPO by HPO neutralizing antibody was utilized and the c hanges of cell proliferation was observed.Results:HPO was expressed by hepatoma cells a nd secreted into the medium.Moreove r,the HPO antibody inhibited specifically the autonomous proliferation of hepatoma cell and antagon ized the stimulatory effect of conce ntrated conditioned medium derived from hep atoma cell HepG2.Conclusion:The results strongly suggest that HPO acts as an autocrine factor to maintain the aut onomous growth of hepatoma cells." @default.
- W2367372457 created "2016-06-24" @default.
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- W2367372457 date "2001-01-01" @default.
- W2367372457 modified "2023-09-28" @default.
- W2367372457 title "Hepatopoietin Is an Autocrine Stimulator for Autonomous Growth in Hepatoma Cell Line" @default.
- W2367372457 hasPublicationYear "2001" @default.
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