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- W2367386987 abstract "Objective: To explore the curative effect of combination of interferon-γ(IFN-γ),N-acetylcysteine and small dosage prednisone on idiopathic pulmonary interstitial fibrosis(IPF).Methods: Thirty one patients with IPF were randomly divided into three groups.Patients in groups A,B,C were treated with low dose prednisone only,low dose prednisone plus IFN-γ,and low dose prednisone plus IFN-γ and N-acetylcysteine respectively.Forced vital capacity(FVC),forced respiratory volume in one second /FVC(FEV1/FVC),maximal vital volume(MVV),total lung capacity(TLC) and PaO2 were detected before treatment and in 4,12,and 24 weeks after treatment.The changes were analyzed.Results: No significant difference was found in FEV1/FVC and measured value/predicting value of MVV before and after treatment in all the 3 groups.In group A,no significant difference was found in PaO2,measured value/ predicting value of FVC and TLC before and after treatment,but in group B and C,the differences were significant(P0.05)and more obvious changes were found in group C.PaO2,measured value/ predicting value of FVC and TLC were higher in group C than those in other two groups,and the differences were significant(P0.05).Conclusions: Combined use of IFN-γ,N-acetylcysteine and low dose prednisone in the treatment of IPF can ameliorate lung function of patients." @default.
- W2367386987 created "2016-06-24" @default.
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- W2367386987 date "2011-01-01" @default.
- W2367386987 modified "2023-09-24" @default.
- W2367386987 title "Curative Effect of Combination of Interferon-γ,N-acetylcysteine and Low Dose Prednisone on Idiopathic Pulmonary Interstitial Fibrosis" @default.
- W2367386987 hasPublicationYear "2011" @default.
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