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- W2367391088 abstract "Objective To investigate the efficacy of luteinizing hormone-releasing hormone agonist( LHRH-A) switching to treat the biochemical recurrence of advanced prostate cancer. Methods Thirty-seven advanced prostate cancer patients who received goserelin or leuprolide treatment and had biochemical progression were rechallenged with the other LHRH-A. The patients were divided into GA-LA group( goserelin followed by leuprolide,n = 26) and LA-GA group( leuprolide followed by goserelin,n = 11). Serum prostatic specific antigen( PSA),testosterone and pain evaluation were achieved following the switching treatment. Results PSA decreased in 16 patients( 61. 54%) in GA-LA group and 7 patients( 63. 64%) in LA-GA group after the LHRH-A switching. The maximum decreases of PSA were 50. 81% and 48. 22% in GA-LA group and LA-GA group,respectively. There were no significant differences in PSA decrease rate and serum testosterone level between two groups at any time points. No pain progression occurred during follow-up. Conclusion Some advanced prostate cancer patients with PSA progression after long term LURH-A treatment would benefit from LHRH-A switching for a short term,which delays the development of castration resistant prostate cancer." @default.
- W2367391088 created "2016-06-24" @default.
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- W2367391088 date "2014-01-01" @default.
- W2367391088 modified "2023-09-23" @default.
- W2367391088 title "Efficacy of luteinizing hormone-releasing hormone agonist switching to treat the biochemical progression of advanced prostate cancer" @default.
- W2367391088 hasPublicationYear "2014" @default.
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