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- W2367396990 abstract "Objective To investigate the expressions of hepatocyte growth factor(HGF) and its receptor proto-oncogene c-Met in cervical carcinoma and their clinical significance.Methods The expressions of HGF mRNA and c-Met mRNA were detected by real-time quantitative reverse transcription-polymerase chain reaction(QRT-PCR) method in 43 cervical carcinoma tissues,30 cervical intraepithelial neoplasm(CIN) Ⅲ tissues and 27 normal cervical tissues.Results The positive expressions of HGF mRNA and c-Met mRNA increased remarkably in cervical carcinoma tissues(P0.05).In cervical carcinoma,the expressions of HGF mRNA and c-Met mRNA were correlated with the clinical stage,tumor size,invasion of deep muscular layer and lymph node metastasis(P0.05),but not with the grade of tumor pathology(P0.05).There was a significant positive correlation between HGF and c-Met in cervical carcinoma(r=0.666,P0.01).Conclusion QRT-PCR used to detect the expressions of HGF mRNA and c-Met mRNA may be an accurate and reliable means for early diagnosis of cervical carcinoma.Over-expression of HGF and c-Met mRNA may both be involved in the invasion and metastasis of cervical carcinoma.Monitoring HGF mRNA and c-Met mRNA would facilitate the treatment and prognosis of cervical carcinoma." @default.
- W2367396990 created "2016-06-24" @default.
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- W2367396990 date "2011-01-01" @default.
- W2367396990 modified "2023-09-23" @default.
- W2367396990 title "Detection of expressions of HGF mRNA and c-Met mRNA in cervical carcinoma with QRT-PCR method" @default.
- W2367396990 hasPublicationYear "2011" @default.
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