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- W2367404470 abstract "Objective: To observe the differences of three bioactive glass materials in repairing rabbit femoral defects,to evaluate the osteogenic potential and biodegradation Property of The Borate Glass Morsels and the other two bioactive glass materials,and to provide the proof for further potential clinical application.Methods: Eighteen healthy New Zealand adult white rabbits were selected to establish bone defects models and randomly assigned into three even groups(with 12 hind legs in each group) for 3 methods of repairing the defects.The 0.6 cm×1.0 to 1.2 cm defects were made at the bilateral femoral condyles of each rabbit.In group A(control group),the NovaBone Bioactive Glass Morsels were implanted;in group B,the NovaBone Bioactive Glass Spheres were implanted;in group C,specimens were collected at 6 and 12 weeks after operation to evaluate the osteogenic and biodegradation properties.Results: No local adverse reaction was observed.At 6 weeks,gradual growth of the new bone was observed inside the implants in groups A,B and C.At 12 weeks,the amount of new bone increased in groups A,B and C,and the moulding of adult bone trabecula was observed.The quantitative analysis of tissue section: after operation of 6 and 12 weeks,in groups B and C,the amount of new bone in bone defect is more than group A(P0.05),and in group C,the amount of new bone in bone defect is more than group B(P0.05).When comparing the amount of survived materials at 6 and 12 weeks after operation,in groups B and C,the amount of survived materials in bone defect is less than the group A(P0.05),and in group C,the amount of survived materials in bone defect is less than group B(P0.05).Conclusion: Compared with the other two biomaterials,the Borate Glass Morsels with spherical appearance not only has good osteogenesis but also has good biodegradation Property.It can effectively repair lacunar bone defects and may be used in clinical." @default.
- W2367404470 created "2016-06-24" @default.
- W2367404470 creator A5070931010 @default.
- W2367404470 date "2013-01-01" @default.
- W2367404470 modified "2023-09-25" @default.
- W2367404470 title "Novel Bioactive Borate Glass to Repair Rabbit Femoral Defects" @default.
- W2367404470 hasPublicationYear "2013" @default.
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