Matches in SemOpenAlex for { <https://semopenalex.org/work/W2367405695> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2367405695 abstract "Objective To investigate the effects of antisense oligonucleotides(ASODN)targeted protein kinase Cα(PKCα)on apoptosis of A549 cells.Methods PKCα ASODN and random oligonucleotides(RODN)were transfected into A549 cells mediated by polyethyleneimine(PEI).①A549 cells were divided into control group,PEI group,PEI-ASODN(1.25,1.50 μmol/L)groups,and the morphology was examined by fluorescence microscope and transmission electron microscope.②A549 cells were divided into control group,PEI group,PEI-RODN(1.50 μmol/L)group,PEI-ASODN(1.00,1.25,1.50 μmol/L)groups.Then the percentage of hypodiploid cells of A549 cells treated with PKCα ASODN for 48 h was determined with propidium iodide(PI)staining by flow cytometry,and the early apoptosis rate was detected with Annexin Ⅴ-FITC and PI dual parameter by flow cytometry.Results Nuclear fragmentation and condensation were observed in A549 cells treated with PKCα ASODN.The percentages of hypodiploid cells and early apoptosis rates increased dose-dependently in PEI-ASODN groups,significantly higher than in control group,PEI group and PEI-RODN group(P0.05).Conclusion The PKCα ASODN mediated by PEI could induce the apoptosis of A549 cells." @default.
- W2367405695 created "2016-06-24" @default.
- W2367405695 creator A5002804384 @default.
- W2367405695 date "2009-01-01" @default.
- W2367405695 modified "2023-09-23" @default.
- W2367405695 title "Antisense oligonucleotides targeted protein kinase C α induces apoptosis of A549 cells" @default.
- W2367405695 hasPublicationYear "2009" @default.
- W2367405695 type Work @default.
- W2367405695 sameAs 2367405695 @default.
- W2367405695 citedByCount "0" @default.
- W2367405695 crossrefType "journal-article" @default.
- W2367405695 hasAuthorship W2367405695A5002804384 @default.
- W2367405695 hasConcept C104317684 @default.
- W2367405695 hasConcept C129312508 @default.
- W2367405695 hasConcept C153911025 @default.
- W2367405695 hasConcept C184235292 @default.
- W2367405695 hasConcept C185592680 @default.
- W2367405695 hasConcept C190283241 @default.
- W2367405695 hasConcept C195794163 @default.
- W2367405695 hasConcept C2775934118 @default.
- W2367405695 hasConcept C31573885 @default.
- W2367405695 hasConcept C54009773 @default.
- W2367405695 hasConcept C54355233 @default.
- W2367405695 hasConcept C552990157 @default.
- W2367405695 hasConcept C553184892 @default.
- W2367405695 hasConcept C55493867 @default.
- W2367405695 hasConcept C74864618 @default.
- W2367405695 hasConcept C81729549 @default.
- W2367405695 hasConcept C86803240 @default.
- W2367405695 hasConcept C88634738 @default.
- W2367405695 hasConcept C95444343 @default.
- W2367405695 hasConceptScore W2367405695C104317684 @default.
- W2367405695 hasConceptScore W2367405695C129312508 @default.
- W2367405695 hasConceptScore W2367405695C153911025 @default.
- W2367405695 hasConceptScore W2367405695C184235292 @default.
- W2367405695 hasConceptScore W2367405695C185592680 @default.
- W2367405695 hasConceptScore W2367405695C190283241 @default.
- W2367405695 hasConceptScore W2367405695C195794163 @default.
- W2367405695 hasConceptScore W2367405695C2775934118 @default.
- W2367405695 hasConceptScore W2367405695C31573885 @default.
- W2367405695 hasConceptScore W2367405695C54009773 @default.
- W2367405695 hasConceptScore W2367405695C54355233 @default.
- W2367405695 hasConceptScore W2367405695C552990157 @default.
- W2367405695 hasConceptScore W2367405695C553184892 @default.
- W2367405695 hasConceptScore W2367405695C55493867 @default.
- W2367405695 hasConceptScore W2367405695C74864618 @default.
- W2367405695 hasConceptScore W2367405695C81729549 @default.
- W2367405695 hasConceptScore W2367405695C86803240 @default.
- W2367405695 hasConceptScore W2367405695C88634738 @default.
- W2367405695 hasConceptScore W2367405695C95444343 @default.
- W2367405695 hasOpenAccess W2367405695 @default.
- W2367405695 hasRelatedWork W1768871930 @default.
- W2367405695 hasRelatedWork W2084498874 @default.
- W2367405695 hasRelatedWork W2125009611 @default.
- W2367405695 hasRelatedWork W2349201178 @default.
- W2367405695 hasRelatedWork W2351114716 @default.
- W2367405695 hasRelatedWork W2357093886 @default.
- W2367405695 hasRelatedWork W2378433516 @default.
- W2367405695 hasRelatedWork W2392330343 @default.
- W2367405695 hasRelatedWork W2392746171 @default.
- W2367405695 hasRelatedWork W2410584079 @default.
- W2367405695 hasRelatedWork W2421675330 @default.
- W2367405695 hasRelatedWork W2430673575 @default.
- W2367405695 hasRelatedWork W2948572249 @default.
- W2367405695 hasRelatedWork W3021821533 @default.
- W2367405695 hasRelatedWork W3029987558 @default.
- W2367405695 hasRelatedWork W3031855783 @default.
- W2367405695 hasRelatedWork W3149564652 @default.
- W2367405695 hasRelatedWork W3150146732 @default.
- W2367405695 hasRelatedWork W3150413245 @default.
- W2367405695 hasRelatedWork W3172744777 @default.
- W2367405695 isParatext "false" @default.
- W2367405695 isRetracted "false" @default.
- W2367405695 magId "2367405695" @default.
- W2367405695 workType "article" @default.