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- W2367406149 abstract "To observe the dynamic change of the protein expression of orphan nuclear receptor nerve growth factor-induced gene B-β(NGFIB-β)in the development of rat retina,and its relationship with the amacrine cells.Methods The embryonate 14 days(E14),16 days(E16),18 days(E18)rats(each 5 cases)and postnatal 0 day(P0),3 days(P3),5 days(P5),6 days(P6),7 days(P7),9 days(P9),13 days(P13),15 days(P15)rats(each 5 cases)were chosen and sacrificed,the eyeballs were enucleated and fixed in formalin,then paraffin-embedded tissue sections were made,the immunohistochemical staining and immunohistochemical double staining were adopted,the results were observed under microscope.Results The expression of NGFIB-β in the development of retina had the obvious dynamic changes.NGFIB-β was firstly expressed in small quantities in the E18 rat retinal tissues,positive expressions were mainly at the inner margin of inner nuclear layer,the positive cells increased with the development of retina and peaked from P3 to P7,then gradually decreased with the maturation of cells,only few were observed in the matured retinal tissues.The immunohistochemical double staining with NGFIB-β and Syntaxin-1(HPC-1,a specific amacrine cell marker of retina)showed that the NGFIB-β positive cells were amacrine cells,the two proteins coexpressed in the same cell.Conclusion NGFIB-β may play an essential role during the differentiation and maturation of the amacrine cells of rat retina." @default.
- W2367406149 created "2016-06-24" @default.
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- W2367406149 date "2010-01-01" @default.
- W2367406149 modified "2023-09-23" @default.
- W2367406149 title "Expression of nerve growth factor-induced gene B-β in development of rat retinal amacrine cells" @default.
- W2367406149 hasPublicationYear "2010" @default.
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